Abstract Background When a randomised trial is subject to deviations from randomised treatment. analysis according to intention-to-treat does not estimate two important quantities: relative treatment efficacy and effectiveness in a setting different from that in the trial. Even in trials of a predominantly pragmatic nature. there may be numerous reasons to consider the extent. https://www.chiggate.com/l-oreal-preference-permanent-hair-colour-4-tahiti-dark-brown-sale/